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KMID : 0607119950020010045
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Inha Medical Journal
1995 Volume.2 No. 1 p.45 ~ p.52
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Cardioprotective Effects of Mg2+ on Arrhythmia in Murine Heart
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Abstract
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Mg2+ has been reported to have therapeutic effect on various kinds of arrhythmia and prevent sudden death associated with arrhythmia in patients with acute myocardial infarction. Hypomagnesemia has been proven to be a important risk factor of
mortality
in cardiovascular disease patients. On the basis of several electrophysiologic studies, Mg2+ is expected to have the membrane stabilizing effects by its action of blocking Na+ and Ca2+ inward currents and by activating Na+ -K+ ATPase. However,
there has
been no study physiologic effects on the whole heart. Therefore this study was performed to evaluate the effects of high Mg2+ Tyrode solution on the murine heart of various states to observe the gross effects of mg2+ and to explain the clinical
benefits
of Mg2+ on the physiologic basis.
1. High mg2+ Tyrode solution decreased the heart rate significantly in comparison no normal Tyrode solution in the heart in the normal state.
2. High mg2+ Tyrode solution decreased the heart rate and depressed the frequency of arrhythmias significantly in comparison to normal Tyrode solution in the heart in the Cs+ induced arrhythmic state.
3. High Mg2+ Tyrode solution depressed the heart rate and prolonged the time to the first beat in comparison to normal Tyrode solution in the heart in the recovery state after cardioplegia
In conclusion. This study demonstrated that Mg2+ decreased the heart rate(negative chronotropic effect) and suppress arrhythmia in the murine heart, and that the clinical benefits of Mg2+ can be explained by its negative chronotropic effect.
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